1.Costunolide covalently targets NACHT domain of NLRP3 to inhibit inflammasome activation and alleviate NLRP3-driven inflammatory diseases
Acta Pharmaceutica Sinica BAvailable online 25 September 2022...
Haowen XuJiahao ChenGuang Liang
温州医科大学
小分子
2.Development of a thermostable SARS-CoV-2 variant-based bivalent protein vaccine with cross-neutralizing potency against Omicron subvariants
Virology20 September 2022...
Rui WangXun HuangLiangzhi Xie
北京义翘神州科技股份有限公司
抗体
3.Interaction of RAGE with α-synuclein fibrils mediates inflammatory response of microglia
Cell Reports20 September 2022...
Houfang LongShengnan ZhangDan Li
中国科学院上海有机化学研究所
蛋白
4.Morphology-driven protein corona manipulation for preferential delivery of lipid nanodiscs
Nano Today11 September 2022...
上海市静安区中心医院
纳米材料
5.Sequence difference of angiotensin-converting enzyme 2 between nonhuman primates affects its binding-affinity with SARS-CoV-2 S receptor binding domain
Biosafety and HealthAvailable online 9 September 2022...
Xiaojun ZhouJingjing ZhaoRui Jia
中国生物技术股份有限公司
蛋白
6.The mechanisms of immune response and evasion by the main SARS-CoV-2 variants
iScience2 September 2022...
Qiuli ChenJiawei ZhangZuyong Zhang
浙江中医药大学
蛋白
7.Aptasensing a class of small molecules based on split aptamers and hybridization chain reaction-assisted AuNPs nanozyme
Food Chemistry29 August 2022...
Sai WangYinglin ZhaoXiangzhao Mao
中国海洋大学
DNA
8.Mechanism investigation of Caspase-8/GSDMC dependent immunogenic cell death induced by Ophiopogonin B in NSCLC cells
Pharmacological Research - Modern Chinese Medicine29 August 2022...
Zhihui LiLing GuMeijuan Chen
南京中医药大学
小分子
9.SIRT1 activation synergizes with FXR agonism in hepatoprotection via governing nucleocytoplasmic shuttling and degradation of FXR
Acta Pharmaceutica Sinica BAvailable online 27 August 2022...
Shuang CuiHuijian HuHaiping Hao
中国药科大学
蛋白
10.Fragments of bombinakinin M exist in lipopolysaccharide-stimulated skin secretions of Bombina maxima and show lipopolysaccharide-neutralizing activity
Journal of Immunological Methods25 August 2022...
Baiyu ZhangSaige YinXinwang Yang
昆明医科大学第一附属医院
小分子
11.Ricin aptamer screening based on the QSAR model and construction of piezoresistive micro-cantilever aptasensor
Talanta18 August 2022...
Zhiwei LiuZhaoyang TongWei Ma
民用nbc防护国家重点实验室
DNA
12.Oxidized tea polyphenol (OTP-3) targets EGFR synergistic nimotuzumab at inhibition of non-small cell lung tumor growth
Bioorganic Chemistry6 August 2022...
Yanping HuangXiangdan CuanJun Sheng
云南农业大学
小分子
13.EGF promotes PKM2 O-GlcNAcylation by stimulating O-GlcNAc transferase phosphorylation at Y976 and their subsequent association
Journal of Biological Chemistry3 August 2022...
Yang WangHengyao ShuMin Wei
东北师范大学
多糖
14.A preliminary cumulative risk assessment of Diethylhexyl phthalate and Dibutyl phthalate based on the inhibition of embryonic development via the PPARγ pathway
Toxicology in Vitro25 July 2022...
Haiqin FangHeng WangJianbo Yan
国家食品安全风险评估中心
小分子
15.Inhibiting STAT3 signaling pathway by natural products for cancer prevention and therapy: In vitro and in vivo activity and mechanisms of action
Pharmacological Research19 July 2022...
Jing YangLingling WangJiang-Jiang Qin
浙江中医药大学
小分子
16.Optimizing component formula suppresses lung cancer by blocking DTL-mediated PDCD4 ubiquitination to regulate the MAPK/JNK pathway
Journal of Ethnopharmacology15 July 2022...
Qianqian FanQinwei LuLei Bi
南京中医药大学
小分子
17.One-step high-throughput detection of low-abundance biomarker BDNF using a biolayer interferometry-based 3D aptasensor
Biosensors and Bioelectronics14 July 2022...
Shunxiang GaoQian LiJihong Wu
上海耳鼻喉医院
DNA
18.Research trends in biomedical applications of two-dimensional nanomaterials over the last decade – A bibliometric analysis
Advanced Drug Delivery Reviews12 July 2022...
Shuang ZhuYaping LiuYuliang Zhao
National Center for Nanoscience and Technology
垂钓
19.Novel donepezil-chalcone-rivastigmine hybrids as potential multifunctional anti-Alzheimer''s agents: Design, synthesis, in vitro biological evaluation, in vivo and in silico studies
Bioorganic Chemistry7 July 2022...
Zhipei SangPing BaiLei Tang
贵州医科大学
小分子
20.Biochemical and structural characterization of a KTSC family single-stranded DNA-binding protein from Euryarchaea
International Journal of Biological Macromolecules7 July 2022...
Lei TianKeli ZhuZhenfeng Zhang
Chinese PLA General Hospital First Medical Center
DNA
21.Re-understanding of structure and anticoagulation: Fucosylated chondroitin sulfate from sea cucumber Ludwigothurea grisea
Carbohydrate Polymers5 July 2022...
Ronghua YinYing Pan Jinhua Zhao
中南民族大学
蔗糖
22.An anti-picornaviral strategy based on the crystal structure of foot-and-mouth disease virus 2C protein
Cell Reports5 July 2022...
Chu ZhangFan YangSheng Cui
Chinese Academy of Medical Sciences and Peking Union Medical College
多肽
23.An emerging paradigm to develop analytical methods based on immobilized transmembrane proteins and its applications in drug discovery
TrAC Trends in Analytical Chemistry4 July 2022...
Qian LiGuowei YinXinfeng Zhao
西北大学
蛋白
24.A facile and integrated aptamer-based platform for preliminary and simultaneous screening of group targets
Sensors and Actuators B: Chemical3 July 2022...
Lele WangRui MaXiangzhao Mao
中国海洋大学
DNA
25.Discovery of Isoform-Selective Akt3 Degraders Overcoming Osimertinib-Induced Resistance in Non-Small Cell Lung Cancer Cells
Journal of Medicinal Chemistry
暨南大学
小分子
26.SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitope
Nature Microbiology volume 7, pages1635–1649 (2022)
Guangzhou Institutes of Biomedicine and Health
抗体
27.Engineering SARS-CoV-2 specific cocktail antibodies into a bispecific format improves neutralizing potency and breadth
Nature Communications volume 13, Article number: 5552 (2022)
西湖大学
抗体
28.Metabolic pathway assembly using docking domains from type I cis-AT polyketide synthases
Nature Communications volume 13, Article number: 5541 (2022)
Shenzhen Institute of Synthetic Biology
蛋白
29.Insulin induces insulin receptor degradation in the liver through EphB4
Nature Metabolism volume 4, pages1202–1213 (2022)
Chinese Academy of Medical Sciences and Peking Union Medical College
蛋白
30.Celastrol recruits UBE3A to recognize and degrade the DNA binding domain of steroid receptors
Oncogene volume 41, pages4754–4767 (2022)
上海生物化学与细胞生物学研究所
蛋白
31.In situ analysis of nanoparticle soft corona and dynamic evolution
Nature Communications volume 13, Article number: 5389 (2022)
Institute of High Energy Physics & National Center for Nanoscience and Technology of China
垂钓
32.LDLR, LRP1, and Megalin redundantly participate in the uptake of Clostridium novyi alpha-toxin
Communications Biology volume 5, Article number: 906 (2022)
西湖大学
蛋白
33.A potent neutralizing antibody provides protection against SARS-CoV-2 Omicron and Delta variants via nasal delivery
Signal Transduction and Targeted Therapy volume 7, Article number: 301 (2022)
中国科学院武汉病毒研究所
抗体
34.Structural insights into partner selection for MYB and bHLH transcription factor complexes
Nature Plants volume 8, pages1108–1117 (2022
复旦大学
蛋白
35.A nanomaterial targeting the spike protein captures SARS-CoV-2 variants and promotes viral elimination
Nature Nanotechnology volume 17, pages993–1003 (2022)
中国科学院深圳先进技术研究院
纳米材料
36.Long non-coding RNA DARS-AS1 promotes tumor progression by directly suppressing PACT-mediated cellular stress
Communications Biology volume 5, Article number: 822 (2022)
清华大学
RNA
37.AvmM catalyses macrocyclization through dehydration/Michael-type addition in alchivemycin A biosynthesis
Nature Communications volume 13, Article number: 4499 (2022)
南京大学
小分子
38.Structural insights into auxin recognition and efflux by Arabidopsis PIN1.
Nature volume 609, pages611–615 (2022)
中国科学技术大学
抗体
39.APOE interacts with ACE2 inhibiting SARS-CoV-2 cellular entry and inflammation in COVID-19 patients
Signal Transduction and Targeted Therapy volume 7,
厦门大学
蛋白
40.Discovery of 2-(1-(3-Chloro-4-cyanophenyl)-1H-pyrazol-3-yl)acetamides as Potent, Selective, and Orally Available Antagonists Targeting the Androgen Receptor
J. Med. Chem. 2022
浙江大学
小分子
41.PDTAC: Targeted Photodegradation of GPX4 Triggers Ferroptosis and Potent Antitumor Immunity
J. Med. Chem. 2022, 65, 18, 12176–12187
北京大学
小分子
42.Exploring the Binding Affinity and Mechanism between ACE2 and the Trimers of Delta and Omicron Spike Proteins by Molecular Dynamics Simulation and Bioassay
J. Chem. Inf. Model. 2022, 62, 18, 4512–4522
中国科学院上海药物研究所
蛋白
43.Insight into Thermodynamic and Kinetic Profiles in Small-Molecule Optimization
J. Med. Chem. 2022, 65, 16, 10809–10847
中国药科大学
蛋白
44.Discovery of a Highly Potent and Selective Dual PROTAC Degrader of CDK12 and CDK13
J. Med. Chem. 2022, 65, 16, 11066–11083
暨南大学
小分子
45.Selective Photoaffinity Probe for Monitoring Farnesoid X Receptor Expression in Cultured Cells
Anal. Chem. 2022, 94, 30, 10722–10729
中国药科大学
小分子
46.Branched Polyethylenimine as a Carrier for Significantly Improving the Biopanning Efficiency of Phages Specific to Hapten
ACS Appl. Polym. Mater. 2022, 4, 8, 5737–5745
中国海洋大学
抗体
47.Schisandrin B Attenuates Diabetic Cardiomyopathy by Targeting MyD88 and Inhibiting MyD88-Dependent Inflammation
https://doi.org/10.1002/advs.202202590
温州医科大学
小分子
48.Substrate-induced dimerization of elaiophylin glycosyltransferase reveals a novel self-activating form of glycosyltransferase for symmetric glycosylation
Acta Crystallographica Section D
Guangzhou Institutes of Biomedicine and Health,
小分子
49.Novel hKDR mouse model depicts the antiangiogenesis and apoptosis-promoting effects of neutralizing antibodies targeting vascular endothelial growth factor receptor 2
https://doi.org/10.1111/cas.15594
National Institutes for Food and Drug Control (NIFDC)
抗体
50.Calycosin protects against oxidative stress-induced cardiomyocyte apoptosis by activating aldehyde dehydrogenase 2
https://doi.org/10.1002/ptr.7591
the Second Affiliated Hospital of Guangzhou Medical University
小分子
51.Novel application of anti-human Fc nanobody for screening high-producing CHO cells for monoclonal antibody
https://doi.org/10.1002/elsc.202200028
Shanghai Bao Pharmaceuticals Co., Ltd.,
抗体
52.Succinylation Inhibits the Enzymatic Hydrolysis of the Extracellular Matrix Protein Fibrillin 1 and Promotes Gastric Cancer Progression
https://doi.org/10.1002/advs.202200546
First Affiliated Hospital of Nanjing Medical University
多肽
53.Vegetable-derived indole enhances the melanoma-treating efficacy of chemotherapeutics
https://doi.org/10.1002/ptr.7565
南京中医药大学
小分子
54.Crucial role of Ca2+/CN signalling pathway in the antifungal activity of disenecioyl-cis-khellactone against Botrytis cinerea
https://doi.org/10.1002/ps.7085
江苏省中国科学院植物研究所
小分子
55.Third-Generation Covalent TMP-Tag for Fast Labeling and Multiplexed Imaging of Cellular Proteins
北京大学
蛋白
56.Development of a variant of dinutuximab with enhanced antitumor efficacy and reduced induction of neuropathic pain
https://doi.org/10.1002/2211-5463.13464
Shanghai Mabstone Biotechonology
抗体
57.Glucose sensing by regulator of G protein signaling 1 (RGS1) plays a crucial role in coordinating defense in response to environmental variation in tomato
https://doi.org/10.1111/nph.18356
浙江大学
细胞
58.Structures, biomimetic synthesis, and anti-SARS-CoV-2 activity of two pairs of enantiomeric phenylpropanoid-conjugated protoberberine alkaloids from the rhizomes of Corydalis decumbens
Archives of Pharmacal Research volume 45, pages631–643 (2022)
澳门科技大学
蛋白
59.Screening and Characterization of Shark-Derived VNARs against SARS-CoV-2 Spike RBD Protein
Int. J. Mol. Sci. 2022, 23(18), 10904
集美大学
蛋白
60.A Sulfated Abalone Polysaccharide Inhibited SARS-CoV-2 Infection of Vero E6 Cells In Vitro
Foods 2022, 11(18), 2865
大连工业大学
多糖
61.A potent synthetic nanobody with broad-spectrum activity neutralizes SARS-CoV-2 virus and the Omicron variant BA.1 through a unique binding mode
Journal of Nanobiotechnology volume 20, Article number: 411 (2022)
The Affiliated Hospital of Qingdao University
抗体
62.A Label-Free Colorimetric Aptasensor Containing DNA Triplex Molecular Switch and AuNP Nanozyme for Highly Sensitive Detection of Saxitoxin
Xiaoyan Qi, Ling Li, Xiaochen Yan, Yinglin Zhao, Lele Wang, Rui Ma, Sai Wang & Xiangzhao Mao
Journal of Ocean University of China volume 21, pages1343–1350 (2022
DNA
63.Identifying the Epitopes of Bacillus thuringiensis Cry2Aa Toxin Involved in Cadherin Interaction by a Monoclonal Antibody
Cheng Shen, Yi-hang Li, Man-man Lin, Jiang-zhao Zhang, Jing Wang, Mei-jing Gao, Xiao Zhang, Xiao-dan Hu, Yuan Liu & Xian-jin Liu
Applied Biochemistry and Biotechnology (2022)
南京农业大学
抗体
64.Optimization of Gonyautoxin1/4-Binding G-Quadruplex Aptamers by Label-Free Surface-Enhanced Raman Spectroscopy
Toxins 2022, 14(9), 622; https://doi.org/10.3390/toxins14090622
海军军医大学
DNA
65.Evolution of Interferon-Gamma Aptamer with Good Affinity and Analytical Utility by a Rational In Silico Base Mutagenesis Post-SELEX Strategy
Beijing University of Chemical Technology
北京化工大学
DNA
66.[Progress of target determination and mechanism of bioactive components of traditional Chinese medicine]
Zhongguo Zhongyao Zazhi
北京中医药大学
小分子
67.Structural Basis of a Novel Agonistic Anti-OX40 Antibody.
Biomolecules 2022, 12(9), 1209
丁浮靶点
抗体
68.CDKN2AIP is critical for spermiogenesis and germ cell development
Yuming Cao, Qi Sun, Zhenlie Chen, Jing Lu, Ting Geng, Ling Ma & Yuanzhen Zhang
Cell & Bioscience volume 12
Zhongnan Hospital of Wuhan University
DNA
69.Galangin Exhibits Neuroprotective Effects in 6-OHDA-Induced Models of Parkinson’s Disease via the Nrf2/Keap1 Pathway
Pharmaceuticals 2022, 15(8), 1014
西南医科大学
小分子
70.Structural Study of SARS-CoV-2 Antibodies Identifies a Broad-Spectrum Antibody That Neutralizes the Omicron Variant by Disassembling the Spike Trimer
Structural Biology
复旦大学
抗体
71.Anti-mesothelin CAR-T immunotherapy in patients with ovarian cancer
Cancer Immunology, Immunotherapy (2022)
南京师范大学
抗体
72.BTApep-TAT peptide inhibits ADP-ribosylation of BORIS to induce DNA damage in cancer
Molecular Cancer volume 21, Article number: 158 (2022)
杭州医学院
多肽
73.Simultaneous Maturation of Single Chain Antibody Stability and Affinity by CHO Cell Display
Bioengineering 2022, 9(8), 360
中科院生物物理研究所
定量
74.The Generation of Dual-Targeting Fusion Protein PD-L1/CD47 for the Inhibition of Triple-Negative Breast Cancer
Biomedicines 2022, 10(8), 1843
上海交通大学
蛋白
75.A Small-Molecule Inhibitor of the Anthranilyl-CoA Synthetase PqsA for the Treatment of Multidrug-Resistant Pseudomonas aeruginosa
Antimicrobial Chemotherapy
浙江工业大学
小分子
76.Cryo-EM structure of the human IgM B cell receptor
SCIENCE VOL. 377
西湖大学
