粒径更小、分布更均匀——揭秘玉研新一代肺部给药装置的突破性升级

• 药物在肺部呈块状或局部高浓度沉积，与真实自然吸入状态存在较大差异；

• 不均匀分布也会导致动物之间的暴露差异增加，从而影响实验重复性和结果一致性。

传统滴注方式在剂量控制方面也存在一定挑战。由于动物气道反射或吞咽动作的存在，部分药液可能会被咳出或吞咽进入消化道，导致真正到达肺部的有效药量下降，从而影响实验准确性。

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