3D单分子荧光成像系统-SAFe 360

SAFe 360是法国abbelight公司推出的一款基于单分子定位的显微成像（SMLM）的新型3D单分子成像系统，它独有的DAISY技术整合了散光技术和超临界角光技术，能够大提高定位精度，xyz三轴定位精度高达15nm，可以提供高清晰三维亚细胞结构图像，支持同时四色成像，可以用于细胞纳米三维成像，观测高清晰亚细胞器结构，实时研究不同的结构功能蛋白的共定位信息，在单分子水平研究分子动力学反应以及细胞间的相互作用等。

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测试数据

发表文章

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[11] Szabo, Quentin, et al. "TADs are 3D structural units of higher-order chromosome organization in Drosophila." Science advances 4.2 (2018): eaar8082. 

[12] Boudjemaa, Rym, et al. "Impact of bacterial membrane fatty acid composition on the failure of daptomycin to kill Staphylococcus aureus." Antimicrobial agents and chemotherapy 62.7 (2018): e00023-18.

[13] Culley, Siân, et al. "Quantitative mapping and minimization of super-resolution optical imaging artifacts." Nature methods 15.4 (2018): 263.

[14] Berger, Stephen L., et al. "Localized myosin II activity regulates assembly and plasticity of the axon initial segment." Neuron 97.3 (2018): 555-570.

[15] Cabriel, Clément, et al. "Aberration-accounting calibration for 3D single-molecule localization microscopy." Optics letters 43.2 (2018): 174-177. 

[16] Bouissou, Anaïs, et al. "Podosome force generation machinery: a local balance between protrusion at the core and traction at the ring." ACS nano 11.4 (2017): 4028-4040. 

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[18] Bourg, Nicolas, et al. "Direct optical nanoscopy with axially localized detection." Nature Photonics 9.9 (2015): 587. 

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