美国达特茅斯学院生物系何冰研究组诚聘专职科研人员

Postdoc and Research Assistant Positions in Tissue Morphogenesis at Dartmouth

Dr. Bing He’s Laboratory at Dartmouth College, New Hampshire is seeking talented postdoctoral scholars and research assistants interested in tissue morphogenesis and quantitative biology. The He Lab studies the molecular and mechanical mechanisms of tissue formation in embryonic development. We useDrosophila, the fruit fly, as our model system because of the array of tools available and its accessibility for live-imaging analyses. By combining cutting-edge imaging techniques with genetics/optogenetics, cell biology and biophysics, our research seeks to address how transcriptional regulatory networks and cell signaling determine the biophysical behaviors of cells that give rise to specific tissue architectures.

Lab Webpage: https://sites.dartmouth.edu/hebing/

Current research topics:

Epithelial folding: Epithelial folding provides a fundamental tissue construction mechanism in embryonic development that converts flat epithelial sheets into convoluted, 3-dimentional structures. Failure in this process can lead to severe congenital birth defects, such as neural tube defects. Using Drosophila gastrulation as the model, we investigate tissue folding mechanisms across subcellular and multicellular scales by exploring the interplay between cell polarity, intracellular trafficking, cytoskeleton and tissue-level mechanics.

Formation of the primary epithelium: Drosophila cellularization is a special form of cleavage that establishes the primary epithelium in the early embryo during maternal-to-zygotic transition. Several important cellular processes occur coordinately during cellularization, including plasma membrane expansion, cytokinesis, and establishment of cell polarity and cell adhesion. We seek to understand how these processes are orchestrated by zygotic gene activities.

Location:The He lab is located in the state-of-the-art Life Sciences Center with access to many well-resourced research facilities that support cutting-edge research in the molecular life sciences (For further information, visit https://biology.dartmouth.edu). We are member of a cross-disciplinary, highly collaborative life sciences research community with a strong commitment to excellence in both research and training. Dartmouth College is a private Ivy League research university located in the rural Upper Valley region of New England, surrounded by vibrant and beautiful neighborhoods that offer an unparalleled quality of life.

Position Requirements: We are looking for candidates who have a strong interest in pursuing research in the field of cell and developmental biology using quantitative and interdisciplinary approaches. Experience with light microscopy and image analysis is preferred.

How to apply: Interested candidates should send a letter describing your interest in the position, CV, and names of three references to Dr. Bing He, Assistant Professor of Biological Sciences, Dartmouth College. 

Molecular and Cell Biology (MCB) Graduate Program: If you are interested in pursuing Ph.D. study in the He Lab, please apply to the MCB Graduate Program at Dartmouth: https://graduate.dartmouth.edu/mcb/

Selected Publications and Preprints:

1. Wei Chen, Victoria Bergstein, Bing He. (2022) PI 4-kinases promote cell surface expansion and facilitate tissue morphogenesis during Drosophila cellularization and gastrulation. Preprint: https://www.biorxiv.org/content/10.1101/2022.09.09.507384v1

2. Melisa A. Fuentes, Hayley N. Piper, Bing He. (2022) Dlg1 regulates subcellular distribution of non-muscle myosin II during Drosophila germband extension. Preprint: https://www.biorxiv.org/content/10.1101/2022.08.29.505652v1

3. Jiayang Chen, Bing He. (2022) Early zygotic gene product Dunk interacts with anillin to regulate Myosin II during Drosophila cleavage. Preprint: https://www.biorxiv.org/content/10.1101/2022.02.14.480462v1

4. Wei Chen, Bing He. (2022) Actomyosin activity-dependent apical targeting of Rab11 vesicles reinforces apical constriction. J Cell Biol. 221(6). doi: 10.1083/jcb.202103069.

5. Hanqing Guo, Michael Swan, Bing He. (2022) Optogenetic inhibition of actomyosin reveals mechanical bistability of the mesoderm epithelium during Drosophila mesoderm invagination. Elife 11:e69082. doi: 10.7554/eLife.69082.

6. Melisa Fuentes, Bing He. (2022) The cell polarity determinant Dlg1 facilitates epithelial invagination by promoting tissue-scale mechanical coordination. Development. 149(6):dev200468. doi: 10.1242/dev.200468.

7. Bing He*, Adam Martin, Eric Wieschaus. (2016) Flow-dependent myosin recruitment during Drosophilacellularization requires zygotic dunk activity. Development 143(13):2417-30. * Corresponding author.

8. Bing He, Konstantin Doubrovinski, Oleg Polyakov, Eric Wieschaus (2014) Apical constriction drives tissue-scale hydrodynamic flow to mediate cell elongation. Nature 508(7496):392-6.

Full list of publications: https://sites.dartmouth.edu/hebing/publications/