N-叔丁基-а-苯基硝酮，3376-24-7，≥95%

中文名：N-叔丁基-а-苯基硝酮

英文名：N-tert-Butyl-α-phenylnitrone

纯度：≥95%

货号：B100838

Cas号：3376-24-7

存储温度：-20°C储存,充氩

产品介绍：

N-tert-butyl-α-phenylnitro?ne (PBN) is a commonly used free-radical spin trap. It has been shown to reduce the number of emboli-induced cerebral microinfarctions in the rabbit cortex and prevent neoplasia by its radical scavenging activity and its ability to inhibit cyclooxygenase-2 activity. Reported to inhibit the induction of nitric oxide synthase (iNOS), thereby preventing the overproduction of nitric oxide (NO). PBN in a dose of 100 mg/kg i.p. reduced necrosis of the substantia nigra, pars reticulate in flurothyl-induced status epilepticus in rats. It protects against some types of post-trauma epileptogenic events in an animal model of epilepsy.The lethal dose of PBN in rats was found to be approximately 100 mg/100 g body weight (0.564 mmol/100? g).一种Cox-2抑制剂。

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