Human Schizophrenia Copy Number PCR Array The Human Schizophrenia qBiomarker Copy Number PCR Array profiles the copy number of 23 genes reported to undergo frequent genomic alterations in schizophrenia. In this mental disorder that typically presents in young adulthood, thought processes break down, emotional responsiveness becomes poor, and significant social or occupational dysfunction often occurs. Mental health professionals diagnose schizophrenia based on observed behavior and reported experiences and treat it mainly with antipsychotic medications, which can have complications, and psychological and social support, which may or may not be wholly effective. Several de novo genomic rearrangements, including copy number variations (CNV), have been identified at specific gene loci in patients with schizophrenia. The genes on the array encode anchoring/scaffolding proteins, cell adhesion molecules, cytoskeletal components, ion transporters, metabolic enzymes, neurotransmitter receptors, and transcription factors. These proteins regulate processes such as axon guidance, signaling (via hormones, nerve growth factors, and neurotransmitters), nervous system development, neurogenesis, synaptic plasticity and synaptic transmission. Genes were chosen from the most frequently amplified or deleted genes relevant to schizophrenia based on a critical review of the primary literature and public databases. This array may serve as a useful tool to help classify samples by genotype and help verify phenotypic biomarkers. The array facilitates the analysis of each gene in each sample in quadruplicate and includes a stable multi-copy reference assay for accurate copy number determination via appropriate DNA input normalization. The simplicity of the product format and operating procedure allows routine and reliable copy number profiling in any research laboratory with access to a real-time PCR instrument.
The qBiomarker Copy Number PCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention, or treatment of a disease.
96-well Plate, 384-well (4 × 96) Plate, and 100-well Disc formats are available
Deletions: ASTN2, CACNG2, CHRNA7, CNTNAP2, EFNA5, ERBB4, GSTM1, MAGI1, NAT1, NAT2, NDE1, NRXN1, PCM1, SELENBP1, SLC1A3.
Duplications: AKAP5, APBA2, CTNND2, GRM7, MYT1L, NDE1, PLA2G4A, SPRY2, VIPR2.
Central Nervous System Development: APBA2, CNTNAP2, EFNA5, ERBB4, MYT1L, NDE1, SLC1A3.
Behavior, Cognition, Learning & Memory: APBA2, CHRNA7, CNTNAP2, CTNND2, GRM7, NRXN1, SLC1A3.
Synaptic Plasticity & Transmission: AKAP5, CACNG2, CHRNA7, CNTNAP2, CTNND2, ERBB4, GRM7, NRXN1, SLC1A3.
Neurotransmitter, Nerve Growth Factor, Neuroendocrine Hormone Receptors & Signaling: CHRNA7, GRM7, SPRY2, VIPR2.
Axon Guidance: CNTNAP2, EFNA5.
Ion Channels: CACNG2, CHRNA7, SLC1A3.
Cell Adhesion: ASTN2, CNTNAP2, CTNND2, MAGI1, NRXN1
Cytoskeleton, Anchoring & Scaffolding: AKAP5, EFNA5, MAGI1, NDE1, PCM1.
Intracellular Transport: APBA2.
Transcription Factors: ERBB4, MYT1L.
Oxidative Stress Response: GSTM1.
Xenobiotic Metabolism: NAT1, NAT2.
Phospholipase: PLA2G4A.
Protease: SPRY2.
Selenium-Binding Protein: SELENBP1
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