大鼠气管内给药套装

小鼠气溶胶肺部给药（气管内给药）套装 / 大小鼠肺部给药装置 (Liquid Aerosol Devices, MicroSprayer® Aerosolizers) 输送气溶胶提供了更好的方案，更方便、更安全、更快捷。 套装主要包括气溶胶雾化喷射头，高压注射器组成。

有两种型号可供选择：大鼠型气管内定量给药套装，小鼠型气管内定量给药套装
 

气管内定量给药装置的主要特色：

• 定量 QUANTIFIABLE：将定量的气溶胶给到动物肺部

• 定时 TIMED：可以在一个或多个时间点进行给药

• 有效 EFFECTIVE：气溶胶的吸收效果好，给药快速，效率高，操作方便

• 方便 CONVENIENCE：维护简单，操作方便

小鼠肺部干粉给药套装：
 

n  产品特点

·  快速 、 精确的直接肺 部给药 ——气溶胶 无 浪费

·  纯机械 动力，无外部空气进入

·  不需加热、 推进剂、超声波或压缩空气 等，对药物物影响

·  手持式设计的独特专利，使用非常方便

·  喷射头顶端圆滑的设计，保证安全、温和的插入气管内

·  可高温高压消毒灭菌，可重复使用

·  比其它雾化器和吸入设备提供更高浓度发药物体积或剂量

·  比传统滴注法给药提供更均匀的药物分布

n  使用方法

Expanding the reach of aerosol drug delivery
Deliver a soft mist directly to the lung with
Penn-Century’s unique liquid and dry powder devices

大小鼠气管内给药装置：
consists of the MicroSprayer® Aerosolizer – Model IA-1C-M and the FMJ-250 High Pressure Syringe, which is required for use of the Model IA-1C devices. The MicroSprayer® Aerosolizer – Model IA-1C-M is designed for fast, targeted, air-free intratracheal aerosol administration to mouse. The device generates a precisely quantifiable, highly-concentrated, air-free plume of liquid aerosol directly into the lungs or other locations. It may also be used for intranasal or in vitro applications. It can aerosolize a wide range of liquids or particle solutions/suspensions, including pharmaceutical, and biologic formulations, contrast/imaging agents and toxicological materials. (It is does not administer dry powders.)
The portion that is inserted into the trachea measures 1.25″. For intrapulmonary applications, the tip of the device is gently inserted down the trachea of the anesthetized animal – near to, but not touching the carina (first bifurcation).
· Quick, precise aerosol dosing directly to the lungs – with no waste
· Purely mechanical, air-free technology
· Uses no heat, propellant, ultrasound or compressed air. No air burden to subject.
· Unique patented design is light, hand-held, easy to use
· Rounded tip permits safe, gentle intratracheal insertion
· Fully sterilizable, autoclavable and reusable
· Delivers a far higher volume and concentration than is possible with nebulizer/inhalation systems
· Produces a far broader, more uniform distribution than liquid bolus/droplet instillation methods


大鼠、小鼠喉镜
小鼠专用喉镜，明亮清晰的照明，更方便观察气管和会厌。
It is makes intratracheal intubation and insertion of Penn-Century’s MicroSprayer® Aerosolizers and Dry Powder Insufflators™ easier, quicker and safer. Each laryngoscope comes with a small, tapered stainless steel blade that is custom-made for use with a specific experimental animal. The blade assembly at the top of the handle is detachable. Additional blade assemblies may be purchased for use with animals of other sizes.
· Long-lasting fiber-optic LED light source offering clear, bright illumination
· Easy-grip handle in a curved ergonomic shape that rests in the palm of the hand
· Handle is coated with non-slip green Santoprene™ rubber
· Long-lasting illumination. Operates with a 3 volt lithium battery provided
· Custom-made stainless steel blade tip for holding aside the animal’s tongue
· Both the handle and detachable blade assembly are sterilizable and autoclavable


大鼠、小鼠气管插管平台
The Mouse Intubation Platform is specially designed to assist researchers working with PennCentury intratracheal aerosol devices or intubation procedures in mice. The Mouse Intubation Platform provides a simple, durable, lightweight, easy-touse system for supporting the anesthetized mouse during intubation and/or insertion of our aerosol delivery devices. Features solid Plexiglass®/Perspex® base and stainless steel support rod, easily attached to any standard lab clamp stand (not included). 
· Special adjustable neck support with Delrin® fittings to facilitate visualization of the trachea.
· Stainless steel posts with plastic “wire” maintain the anesthetized animal in the correct position for intubation, suspended from the front incisors.
· Two side posts to secure the mouse on its back with a rubber band.
· Additional, adjustable stainless steel side posts prevent lateral movement of the mouse during intubation

 

参考文献：

1. Li, Cheng et al. “Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody.” Cell vol. 185,8 (2022): 1389-1401.e18. doi:10.1016/j.cell.2022.03.009

2. Peng, Boya et al. “Robust delivery of RIG-I agonists using extracellular vesicles for anti-cancer immunotherapy.” Journal of extracellular vesicles vol. 11,4 (2022): e12187. doi:10.1002/jev2.12187

3. Wu, Lan et al. “Poly(lactide-co-glycolide) Nanoparticles Mediate Sustained Gene Silencing and Improved Biocompatibility of siRNA Delivery Systems in Mouse Lungs after Pulmonary Administration.” ACS applied materials & interfaces vol. 13,3 (2021): 3722-3737. doi:10.1021/acsami.0c21259

4. Tian, Xidong et al. “Pulmonary Delivery of Reactive Oxygen Species/Glutathione-Responsive Paclitaxel Dimeric Nanoparticles Improved Therapeutic Indices against Metastatic Lung Cancer.” ACS applied materials & interfaces vol. 13,48 (2021): 56858-56872. doi:10.1021/acsami.1c16351

5. Gu, Peiyu et al. “Protective function of interleukin-22 in pulmonary fibrosis.” Clinical and translational medicine vol. 11,8 (2021): e509. doi:10.1002/ctm2.509

6. Su, Ruonan et al. “Venetoclax nanomedicine alleviates acute lung injury via increasing neutrophil apoptosis.” Biomaterials science vol. 9,13 (2021): 4746-4754. doi:10.1039/d1bm00481f

7. Yang, Huilin et al. “Triptolide dose-dependently improves LPS-induced alveolar hypercoagulation and fibrinolysis inhibition through NF-κB inactivation in ARDS mice.” Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie vol. 139 (2021): 111569. doi:10.1016/j.biopha.2021.111569

8. Wu, Yanqi et al. “SN50 attenuates alveolar hypercoagulation and fibrinolysis inhibition in acute respiratory distress syndrome mice through inhibiting NF-κB p65 translocation.” Respiratory research vol. 21,1 130. 27 May. 2020, doi:10.1186/s12931******/span>

9. Han, Meishan et al. “Engineering of Stimulus-Responsive Pirfenidone Liposomes for Pulmonary Delivery During Treatment of Idiopathic Pulmonary Fibrosis.” Frontiers in pharmacology vol. 13 882678. 25 Apr. 2022, doi:10.3389/fphar.2022.882678

10. Wu, Lan et al. “Quantitative comparison of three widely-used pulmonary administration methods in vivo with radiolabeled inhalable nanoparticles.” European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V vol. 152 (2020): 108-115. doi:10.1016/j.ejpb.2020.05.004

11. Peng, Jianqing et al. “Carboxymethyl Chitosan Modified Oxymatrine Liposomes for the Alleviation of Emphysema in Mice via Pulmonary Administration.” Molecules (Basel, Switzerland) vol. 27,11 3610. 4 Jun. 2022, doi:10.3390/molecules27113610

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