The DCode universal mutation detection system has a vertical electrophoresis cell with adaptors for different techniques for identification of single-base changes, providing a simple, efficient, and flexible system for screening and identifying polymorphisms. Use the same system for high-throughput screening for a mutation or hunting for unknowns. The DCode system can identify single-base changes using any combination of the following electrophoretic techniques: Single-stranded conformation polymorphism (SSCP) Denaturing gradient gel electrophoresis (DGGE) Constant denaturing gel electrophoresis (CDGE) Temporal temperature gradient gel electrophoresis (TTGE) A unique feature of the DCode system is the ability to perform TTGE. This type of analysis, codeveloped by Bio-Rad, has the advantage of not using a denaturing chemical gradient gel, as is required for DGGE and to optimize CDGE. The denaturing chemical gradient is replaced with a linear temperature gradient, eliminating the need for casting gradient gels. TTGE provides faster, simpler and increased reproducibility of detection of single-base changes. Features of the DCode universal mutation detection system: Run up to 64 samples in as