非接触式亚微米分辨红外拉曼同步测量系统

参考文献：Super‐Resolution Infrared Imaging of Polymorphic Amyloid Aggregates Directly in Neurons.

测试数据

1、多层薄膜

2、高分子

高分子膜缺陷。左：尺寸为240 μm的两层薄层上缺陷的光学图像； 右：在无缺陷处（红色）和缺陷处（蓝色）的样品的IR谱图，998 cm-1处为of isotactic polypropylene 的特征红外吸收峰

环氧树脂包埋聚苯乙烯球的亚微米分辨O-PTIR线扫描 PS和PMMA微塑料混合物的亚微米红外拉曼同步O-PTIR 光谱和成像分析

3、生命科学 

4、医药领域

左：PLGA高分子和Dexamethasone药物分子的混合物表面的光学照片
中：在1760 cm^-1 出的高光谱图像，显示了 PLGA在混合物中的分布，图像尺寸40 μm * 40 μm 

右：在1666 cm^-1 出的高光谱图像，显示了 Dexamethasone在混合物中的分布，图像尺寸40 μm *40 μm

5、法医鉴定

左：800 nm纤维的光学照片

右：纳米纤维不同区域的O-PTIR图谱

6、其他领域

•  故障分析和缺陷

•  微电子污染

•  食品加工

•  地质学 

•  考古和文物鉴定

发表文章

[1] Depth-resolved mid-infrared photothermal imaging of living cells and organisms with submicrometer spatial resolution, Ji-Xin Cheng et al., Sci. Adv. 2016, 2, e1600521.

[2] Mid-Infrared Photothermal Imaging of Active Pharmaceutical Ingredients at Submicrometer Spatial Resolution, Ji-Xin Cheng et al., Anal. Chem. 2017, 89, 4863-4867.

[3] Label-Free Super-Resolution Microscopy. Springer, Biological and Medical Physics, Biomedical Engineering.

[4] Advances in Infrared Microspectroscopy and Mapping Molecular Chemical Composition at Submicrometer Spatial Resolution, Spectroscopy 2018.

[5] Evolution of a Radical-Triggered Polymerizing High Internal Phase Emulsion into an Open-Cellular Monolith, Macromolecular Chemistry and Physics, 2019.

[6] A Global Perspective on Microplastics, Journal of Geophysical Research: Ocean, 2019.

[7] Super-Resolution Infrared Imaging of Polymorphic Amyloid Aggregates Directly in Neurons (Front Cover), Advanced Science, 2020.

[8] Self-formed 2D/3D Heterostructure on the Edge of 2D Ruddlesden-Popper Hybrid Perovskites Responsible for Intriguing Optoelectronic Properties and Higher Cell

Efficiency, Applied Physics, 2020.

[9] Two-Dimensional Correlation Analysis of Highly Spatially Resolved Simultaneous IR and Raman Spectral Imaging of Bioplastics Composite Using Optical Photothermal Infrared and Raman Spectroscopy, The Journal of Molecular Structure, 2020.

[10] Super resolution correlative far-field submicron simultaneous IR and Raman microscopy: a new paradigm in vibrational spectroscopy, Advanced Chemical Microscopy for Life Science and Translational Medicine, 2020.

[11] Submicron-resolution polymer orientation mapping by optical photothermal infrared spectroscopy, International Journal of Polymer Analysis and Characterization, 2020.

[12] Bulk to nanometre-scale infrared spectroscopy of pharmaceutical dry powder aerosols, Analytical Chemistry, 2020.

[13] Optical Photothermal Infrared Micro-Spectroscopy – A New Non-Contact Failure Analysis Technique for Identification of<10mm Organic Contamination in the Hard drive and other Electronics Industries. Microscopy Today, 2020.

[14] Spontaneous Formation of 2D-3D Heterostructures on the edges of 2D RuddlesdenPopper Hybrid Perovskite Crystals, Chemistry of Materials, 2020.

[15] Simultaneous Optical Photothermal Infrared (OPTIR) and Raman Spectroscopy of Submicrometer Atmospheric Particles, Analytical Chemistry, 2020.

[16] Detection of high explosive materials within fingerprints by means of optical-photothermal infrared spectromicroscopy, Analytical Chemistry, 2020.

[17] Polarized O-PTIR of collagen and individual fibril strands reveals orientation, Molecules Special Edition: “Biomedical Raman and Infrared Spectroscopy: Recent Advancement and Applications, 2020.

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