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工商注册信息已核实!领域: | 化学药,纳米材料,高分子材料 | ||
样品: | Petasis reactions | 项目: | Petasis reactions离子液体 |
We have used a design of experiments (DOE) approach to optimise rapidly a set of microwave assisted conditions for the Petasis reaction. The optimal conditions involved the microwave heating of the reaction components in dichloromethane (1M concentration) at 120℃ for 10 min in a focussed microwave (CEM Explorer). These conditions were successfully applied to a range of Petasis reactions employing either glyoxylic acid or salicylaldehyde as the carbonyl component along with a number of aryl/heteroaryl boronic acids and amine components.