分析测试百科网 认证会员,请放心拨打!
诚信认证:
工商注册信息已核实!安捷伦中国在2019年卓越职场Great Place to Work®评选活动中金榜题名,荣膺大中华区最佳职场™,且位列前五,以及大中华区女性最佳职场™。点击了解更多
领域: | 化妆品 | ||
样品: | 水中药物和个人护理用品 | 项目: | 水中药物和个人护理用品的高灵敏度筛查 |
参考: | - |
方案文件名 | 下载 |
---|---|
水中药物和个人护理用品的高灵敏度筛查 |
下载此篇方案 |
As a follow up to the Application Note on detection of pharmaceuticals and
personal care products (PPCPs) in water using the Agilent 6495 Triple Quadrupole
Mass Spectrometer
8
, this Application Note describes two methods to screen and
quantitate PPCPs in water at part per trillion (ppt) levels using the Agilent 6545
Q
-
TOF LC/
MS System. Similarly, the methods were divided into positive ion mode
and negative ion mode due to the unique mobile phases used for the two methods.
The precise and accurate screening and quantitation of 118 compounds in
positive ion mode and 22 compou
nds in negative mode was accomplished on the
6545 Q
-
TOF LC/MS using the Swarm tune parameters optimized for small fragile
organic molecules. The high sensitivity slicer mode was selected to maximize
instrument sensitivity. Most of the PPCPs could be det
ected without tedious
analyte enrichment such as solid phase extraction (SPE). The extent of sample
preparation included filtering approximately 3 mL of sample, adding internal
standards to a 1.0 mL aliquot of the filtered sample, and injecting 40 μL of
sample
for analysis by Q
-
TOF LC/MS with reporting limits for the majority of analytes at
10 ppt. The limit of detection (LOD) and lower limit of quantitation (LLOQ) for most
of the analytes are much lower than 10 ppt
扫描下方二维码,关注“安捷伦视界”微信公众号,获取更多解决方案资讯。