怎样使用反气相色谱进行科学研究

怎样使用反气相色谱进行科学研究

   在设计和制造复杂混合物和配方的过程中，借助于了解样品的理化参数来表示的组分的性质很重要。它使您能够评估这些材料是否适合预期的应用。通常，了解和量化给定系统组分之间的交互至关重要。组分间相互作用的可以通过反气相色谱（IGC）来实现。这些相互作用在粘附，润湿，溶胀或溶解过程中很重要。

   在本讲座中，将介绍IGC的一些独特应用。

   我们希望显示IGC在评估酚醛树脂储存期间的理化变化方面的应用。而且，可以快速评估在不同条件下储存期间的化学变化，而无需复杂的样品制备。

   对于固体非挥发性药物活性物质，也可以成功确定制药工业中使用的一系列赋形剂的Hansen溶解度参数。还将讨论各种因素对使用IGC确定溶解度参数的值和精度的影响。

   通过IGC检查牛牙组织的表面能。结果表明，组织类型和发生位置对表面能的分散和特定（酸碱）成分的值以及表面能的总值影响最大。

作者：Adam Voelkel, Poznan University of Technology,

         Faculty of Chemical Technology, Poznan, Poland

      Knowledge of the properties of components expressed by means of physicochemical parameters is important in the processes of designing and manufacturing complex mixtures and formulations. It enables to assess the suitability of these materials for the intended applications. Very often, understanding and quantifying the interactions between components of a given system is crucial. This may be achieved by applying Inverse Gas Chromatography (IGC). These interactions are important in the processes of adhesion, wetting, swelling or dissolving.

In this lecture some unique applications of IGC will be presented.

We like to show application of IGC in the assessment of the physicochemical changes during the phenolic resins storage. Moreover, it makes possible to assess the chemical changes during storage at the different conditions quick and without need of the complicated sample preparation.

Hansen Solubility Parameters for a series of excipients used in the pharmaceutical industry might be successfully determined also for the solid, non-volatile pharmaceutically active materials. The influence of various factors on the value and precision of determining the solubility parameter using IGC will be also discussed.

Surface energy of bovine tooth tissues was examined by means of IGC. Results show that the type of tissue and occurring place have the greatest impact on the values of dispersive and specific (acid–base) component of surface energy and total value of surface energy.