北京毅新博创生物科技有限公司
诚信认证:
工商注册信息已核实！
扫一扫即可访问手机版展台
- Identification of Lactobacillus from the Saliva of Adult Patients with Caries Using Matrix-Assisted Laser Desorption/Ionization Time-Of-Flight Mass Spectrometry
- Serum Proteomic Profiling for the Early Diagnosis of Colorectal Cancer
- Magnetic Bead-Based Salivary Peptidome Profiling Analysis for Severe Early Childhood Caries
- Salivary biomarkers indicate obstructive sleepapneapatientswithcardiovascular diseases
- Identification of Kininogen-1 as a Serum Biomarker for the Early Detection of Advanced Colorectal Adenoma and Colorectal Cancer
Salivary biomarkers indicate obstructive sleepapneapatientswithcardiovascular diseases
| 领域： | 蛋白/抗体/蛋白质组 | ||
| 资料类型： | NONE | ||
下载地址2：Salivary biomarkers indicate obstructive sleepapneapatientswithcardiovascular diseases
Abstract:
Although obstructive sleep apnea (OSA) patients are at high risk of developing cardiovascular disease (CVD), only a small proportion is currently diagnosed. To explore and identify the differentially expressed proteins/peptides of OSA patients with CVDs, a mass spectrometry-based salivary analysis was performed. In our study, eleven peaks were observed differentially expressed in saliva from the non-CVD and CVD groups. Five masses mass peaks (1594.1, 1673.7, 1196.6, 1290.5, and 1447.0 Da) showed an upregulated trend in the CVD group, whereas six mass peaks (3038.6, 2164.3, 2301.4, 3195.0, 2628.4, and 1721.9 Da) were downregulated in the CVD group. In addition, the alpha-2-HS-glycoprotein (AHSG) levels in saliva were verified to be decreased in CVD group compared to non-CVD group. Analysis of the salivary peptidome provides a promising approach to screening for novel biomarkers before further identification, and may contribute to early diagnosis of CVD patients with OSA.