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- Identification of Lactobacillus from the Saliva of Adult Patients with Caries Using Matrix-Assisted Laser Desorption/Ionization Time-Of-Flight Mass Spectrometry
- Serum Proteomic Profiling for the Early Diagnosis of Colorectal Cancer
- Magnetic Bead-Based Salivary Peptidome Profiling Analysis for Severe Early Childhood Caries
- Salivary biomarkers indicate obstructive sleepapneapatientswithcardiovascular diseases
- Identification of Kininogen-1 as a Serum Biomarker for the Early Detection of Advanced Colorectal Adenoma and Colorectal Cancer
Identification of Kininogen-1 as a Serum Biomarker for the Early Detection of Advanced Colorectal Adenoma and Colorectal Cancer
发布时间：
2016-02-19 14:50
来源：北京毅新博创生物科技有限公司
| 领域： | 蛋白/抗体/蛋白质组 | ||
| 资料类型： | NONE | ||
Abstract
Background: Serum markers represent potential tools for the detection of colorectal cancer (CRC). The aim of this study was to obtain proteomic expression profiles and identify serum markers for the early detection of CRC.Methods: Proteomic profiles of serum samples collected from 35 healthy volunteers, 35 patients with advanced colorectal adenoma (ACA), and 40 patients with CRC were compared using Clinprot technology. Using enzyme linked immunosorbent assays (ELISAs), 366 sera samples were additionally analyzed, and immunohistochemistry studies of 400 tissues were used to verify the expression of kininogen-1 and its value in the early detection of CRC.