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使用在线样品前处理液质联用技术筛选和定量尿中多种药物
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使用在线样品前处理液质联用技术筛选和定量尿中多种药物 |
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前言：
Liquid chromatography-mass spectrometry (LC-MS) is a sensitive, accurate, and precise technique applied in clinical research for the analysis of a large number of compounds and metabolites from various drug classes, such as antidepressants, hypnotics, stimulants, cardiacs, and antihistamines. Thermo Scientific Transcend system powered by TurboFlow™ technology provides an alternative separation technique for complex biomatrices, simplifying sample preparation, increasing LC-MS/MS sensitivity, and reducing ion suppression.
仪器：
Thermo Scientific TSQ Quantum mass spectrometer
结论：
An efficient (9 minute), sensitive (LOQ of 1-50 ng/mL), and precise LC-MS/MS method using TurboFlow technology was developed for the quantitation of 30 drugs in human urine. In clinical research, TurboFlow technology simplifies sample preparation and improves method robustness and sensitivity.
