HPLC-MS/MS检测动物源食品中6种玉米赤霉醇残留量

前言：

　　Zeranol is a non-steroidal estrogenic growth stimulator that is widely used in food-producing animals in the United States and other countries. A synthetic derivative of the mycotoxin zearalenone, zeranol is a potential endocrine disrupter that may have adverse effects on humans, such as birth defects and reproductive disorders, because of its hormone-like properties.1 In addition, zeranol residues in animal-derived food may increase human breast cancer risks by acting like estrogen in the body and stimulating estrogen-modulated genes that promote carcinogenesis.2 The use of zeranol in the livestock industry may also cause secondary pollution and environmental contamination of drinking water and foods.

　　Because of the potential health concerns, the use of zeranol and other anabolic growth promoters in food animals is banned in the member states of the European Union (EU), China, and other countries. Therefore, highly sensitive and specific methods with low levels of detection are needed to analyze zeranol residues in edible tissues. Here an LC-MS/MS method is established to detect zeranol (α-zearalanol) and its main metabolites, β-zearalanol and zearalanone, and the mycotoxin zearalenone and its metabolites, α-zearalenol and β-zearalenol, in animal-derived foods, such as pork, beef, lamb, chicken liver, milk, and eggs.

仪器：

Thermo Scientific TSQ Quantum mass spectrometer

结论：

　　The LC-MS/MS method described here is able to detect zeranol residues from animal-derived foods, such as pork, beef, lamb, chicken liver, milk, and eggs. The method yielded high recovery rates and enabled the accurate quantification of the residues. The sensitivity, extraction recovery, and reproducibility of this method meet international regulation and detection requirements.