使用离线提取LC-MS/MS技术测定软体动物中亲脂性海洋生物毒素

前言：

　　In recent years many countries have had to deal with the consequences of toxic microalgal blooms in both marine and fresh water, such as the deaths of wild animals and domestic livestock.

　　Several cases of poisoning in humans have been associated with the direct consumption of shellfish, fish, or water contaminated by algal toxins. People may also come into contact with toxins during recreational activities along sea coasts affected by episodes of algal blooms. Depending on the type of toxin involved, there are forms of mild and usually self-limiting symptoms, characterized by gastrointestinal disorders or allergic-like episodes. Much more severe symptoms of the neurological type can lead to death.

仪器：

Thermo Scientific TSQ Quantum mass spectrometer

结论：

　　This method proved to be selective, sensitive, accurate, and reproducible. It can be successfully applied for the quantitative determination of several classes of lipophilic marine biotoxins in bivalve mollusc samples.