离子阱和三重四极杆MS用于FAIMS药物发现和开发

前言：

The selective removal of interferences present in complex biological matrices such as plasma, urine and food, as well as interferences found in common drug vehicles, such as polymers, by using high-Field Asymmetric waveform Ion Mobility Spectrometry (FAIMS) technology coupled with a triple stage quadrupole or ion trap mass spectrometer.

Methods: Direct sample infusion, as well as liquid chromatography (LC) coupled with FAIMS and a triple quadrupole mass spectrometer, and LC coupled with FAIMS and an ion trap mass spectrometer.

仪器：Thermo Scientific TSQ Vantage, Thermo Scientific LTQ Orbitrap XL

结论：

FAIMS effectively removed the interference peaks contained in the samples using both the ion trap and triple quadrupole mass spectrometers. Quantitative samples analyzed using FAIMS and a triple quadrupole improved the limits of detection (LOD) by 10X and limit of quantification (LOQ) by more than 5X.