三重四极杆质谱仪定量血浆中极低浓度的卡麦角林

前言：

Quantitation of low plasma concentrations of the pharmaceutical cabergoline is performed to demonstrate the sensitivity and selectivity of Thermo Electron’s Finnigan™ TSQ™ Quantum mass spectrometer.Samples with analyte concentrations ranging five orders of magnitude are analyzed to demonstrate precision and accuracy over a linear dynamic range suitable for pharmacokinetic applications. Analysis of 50 fg of cabergoline on column in minimally treated plasma samples is performed to demonstrate the sensitivity, ruggedness, and practicality of the bioanalytical method in a complex matrix.

仪器：

TSQ Quantum mass spectrometer

结论：

The TSQ Quantum operated at unit resolution shows tremendous utility in the development of highly sensitive detection methods for ergoline derivatives such as cabergoline. Sensitivity on the TSQ Quantum is ~20 times better than that reported on the TSQ 7000 while only requiring a fraction of the sample previously used.

Furthermore, analysis of low plasma concentrations of cabergoline was performed in a complex, minimally treated plasma matrix. The broad dynamic range of the TSQ Quantum, coupled with the excellent precision and accuracy in unit resolution, is of particular importance for applications where detector saturation is typically encountered. The broad dynamic range, therefore, allows for easy development of methods suitable for the analysis of drugs administered at any given dose (low and high), for drugs and their metabolites, and for drug combination products. For these reasons, the TSQ Quantum should find widespread use in the development of sensitive, simple, fast, accurate, and rugged methods for many pharmacokinetic applications