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领域: | 化学药,生物制药/仿制药,临床血液与检验学 | ||
样品: | 人血浆 | 项目: | 去氨加压素 |
参考: | Neudert, L.; Zaugg, M.; Wood, S.; Struwe, P. A High Sensitivity Dual Solid Phase Extraction LC-MS/MS Assay for the Determination of the Therapeutic PeptideDesmopressin in Human Plasma |
方案文件名 | 下载 |
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高选择性和高精度的人血浆中去氨加压素分析 |
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The results presented demonstrate the successful development of an accurate, precise, and selective SPE-LC-MS/MS method for the analysis of desmopressin from human plasma. Use of micro-elution SPE allowed for concentration of the sample prior to analysis without the need for post-extraction processing. Utilizing SOLAµ mixed-mode SPE provided both a clean and repeatable extract across the concentration range.
结果表明, 该方法成功地研制出了一种精确、精确、选择性的 SPE-LC-MS/MS方法,用于分析人血浆中的去氨加压。使用微洗脱SPE 可以浓缩样品,在仪器分析前不需要后提取步骤。利用 SOLAµ混合模式 SPE,实现了在整个浓度范围内干净、可重复性的提取。