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GC-MS应用EPA方法分析饮用水中的SVOC

发布时间: 2011-05-13 07:40 来源:赛默飞色谱与质谱分析
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GC-MS应用EPA方法分析饮用水中的SVOC.pdf

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  Overview

  The United States Environmental Protection Agency (US EPA) Method 525.2 is a general purpose method for the gas chromatograph/ mass spectrometer (GC/ MS) analysis of organic compounds in source water, finished drinking water, or drinking water at any stage of treatment. 1 This method presents a number of analytical challenges, including target compounds of varying polarity and with wide ranges of stability. To address these challenges and to streamline method development and validation processes, a Productivity Solution was developed for US EPA Method 525.2 using the DSQ TM II single quadrupole mass Spectrometer,along with a TRACE GC UltraTM and and AS

  3000 liquid autosampler. This Productivity Solution (Thermo Scientific PN 120296-KIT) incorporates the appropriate hardware, software, metho do logies and consumables required to meet the demanding quality control (QC) criteria laid out by the method. The solution provides optimal performance of Method 525.2 by balancing sample throughput, robustness, and ease of use. Rigorous method development and validation processes ensure that the Productivity Solution for US EPA Method 525.2 for the DSQ TM II GC/ MS system satisfies the demanding requirements of this method.

  An instrument method was developed ior the DSQ TM II GC/ MS system. A surged splitless injection with an injection volume of I liL allowed for sample introduction, and the oven was programmed to ensure that the chromatography met the method requirements for resolution of critical compound pairs. All compounds eluted in less than 25 minutes. The DSQ II mass spectrometer acquired EI full scan data, with a mass range of m/z 45 to 450. Maintenance included daily replacement of the inlet septum but no other routine maintenance was required due to the relative cleanliness of the samples. For sample identification and quantification, processing methods and Enviro Lab' M Forms 2.0 methods were also developed and integrated into the Productivity Solution. During the method development phase of the project, the robustness of the hardware was evaluated by running the application ior several months. Finally, consumables and standards were carefully evaluated and selected based upon their performance for the method.

  By combining the Productivity Solution for US EPA Method 525.2 with the DSQ TM II GC/ MS system, detection limits were achieved that far surpass those described in the method, even for challenging compounds. Across a calibration range irom 0.1 to 10.0 ng/ liL, the average % RSD across the entire target list was 9.2% and all compounds met average response tact or or linear fit calibration criteria. Instrument detection limits ranged from 0.014 µg/ L for stir oios to 0.49 µg/ L for pentachlorophenol, with a GC run time of approximately 30 minutes. Enviro Lab Forms 2.0 sofnivare provided data acquisition, processing and reporting capabilities that streamlined data

  review, ensured QC criteria were met and allowed for reporting of all study results. The 525.2 Productivity Solution simplified method development and validation by providing pre-developed templates for Initial Calibration, Method Detection Limit determinations, and daily batches. A Standard Operating Procedure and How To Manual with a Quick Start Guide facilitated installation of the application.2,3,4

  Instruments

  DSQ TM II GC/ MS system

  Conclusion

  Dedicated analyzers ensure high sample throughput in the lab. When the entire GC/ MS system has been proven to produce the performance requiredin the EPA Method, tight QC criteria can easily be met on a day to day basis. The Productivity Solution for US EPA Method 525.2 has been validated in the iactory to meet all of the QC criteria listed in the method. Pre-validated consumables make daily operation oi the system routine. The DSQ II showed excellent sensitivity and linear range ior the analytes studied. Enviro Lab Forms reporting software produced all of the required QC reports automatically at the end of each run.

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