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Proteomic Interrogation of Primary Insulin-secreting Pancreatic β-cells

发布时间: 2020-09-18 16:52 来源: 布鲁克(北京)科技有限公司-质谱仪器

下载地址: Proteomic Interrogation of Primary Insulin-secreting Pancreatic β-cells


The combination of integrated ion mobility with warp-speed MS/MS acquisition on the timsTOF Pro paves the way for deep, molecular level understanding of β-cell physiology and potential new targetable pathways for diabetes.


In this work we leveraged the analytical performance of the  timsTOF Pro to identify expression of low-level enzymes for  the first time in primary insulin-secreting beta cells (β-cells). We  found that these proteins are critical, functional components of  key metabolic pathways which  can support β-cell survival under  inflammatory stress, an emerging disease etiology of diabetes.Confirmation that these factors  are present and functional specifically in pancreatic β-cells points  to new therapeutic avenues for  human diabetes.


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