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Proteomic Interrogation of Primary Insulin-secreting Pancreatic β-cells
| 领域： | 蛋白/抗体/蛋白质组 | ||
| 样品： | Primary human islets | 项目： | 质谱 |
| 参考： | - | ||
| 方案文件名 | 下载 |
|---|---|
Proteomic Interrogation of Primary Insulin-secreting Pancreatic β-cells |
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The combination of integrated ion mobility with warp-speed MS/MS acquisition on the timsTOF Pro paves the way for deep, molecular level understanding of β-cell physiology and potential new targetable pathways for diabetes.
In this work we leveraged the analytical performance of the timsTOF Pro to identify expression of low-level enzymes for the first time in primary insulin-secreting beta cells (β-cells). We found that these proteins are critical, functional components of key metabolic pathways which can support β-cell survival under inflammatory stress, an emerging disease etiology of diabetes.Confirmation that these factors are present and functional specifically in pancreatic β-cells points to new therapeutic avenues for human diabetes.
