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C&EN封面故事--质谱成像探秘药物在组织中的分布
| 领域： | 蛋白/抗体/蛋白质组,基因/基因组/测序,多组学/蛋白质组/代谢组/脂质组,生物制药/仿制药,其他 | ||
| 资料类型： | 其他资料 | ||
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C&EN封面故事--质谱成像探秘药物在组织中的分布 |
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Sometimes it's not enough to know how much drug has reached a particular tissue.
Sometimes you need to know where in that tissue the drug has gone.
To answer that and other questions, pharmaceutical companies are turning to imaging mass spectrometry. It allows pharma scientists to collect information about drug distribution much earlier in the discovery process than previously possible.
The resulting pictures are helping drug developers prevent toxicity and off-target effects.
MS imaging helps visualize earlystage fibrosis in a rat liver (top) by showing the location of hepatocytes (blue), fibrotic bands (green), and the portal vein (red). In the center image, the MS data are overlaid on the conventional histology image (bottom).
