氟肟 Palladacycle: 在水和有机介质中碳-−碳偶联反应的预催化

领域：纳米材料,高分子材料    样品：氟肟 Palladacycle    项目：碳-−碳偶联反应的预催化    参考：J. Org. Chem. 2012, 77, 2729 − 2742   

Fluorous Oxime Palladacycle: A Precatalyst for Carbon − Carbon Coupling Reactions in Aqueous and Organic Medium

J. Org. Chem. 2012, 77, 2729 − 2742

摘要：

To facilitate precatalyst recovery and reuse, we have developed a fluorous, oxime-based palladacycle 1 and demonstrated that it is a very efficient and versatile precatalyst for a wide range of carbon − carbon bond formation reactions (Suzuki − Miyaura, Sonoga-shira, Stille, Heck, Glaser-type, and Kumada) in either aqueous or

organic medium under microwave irradiation. Palladacycle 1 could be recovered through F-SPE in various coupling reactions with recovery ranging from 84 to 95% for the first cycle. Inductively coupled plasma optical emission spectrometry (ICP-OES) analyses of the Pd content in the crude product from each class of transformation indicated

extremely low levels of leaching and the palladacycle could be reused four to five times without significant loss of activity.